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KMID : 1123920090230040895
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Korean Journal of Oriental Physiology and Pathology
2009 Volume.23 No. 4 p.895 ~ p.897
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Anti-mechanical Hyperalgesic Effect of Lonicera Japonica in Neuropathic Pain Rats
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Hwang Hye-Jeong
Kim Hee-Young
Lee Hye-Jung
Lee Bae-Hwan
Shim In-Sop
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Abstract
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Lonicera japonica has been widely used for chronic inflammatory diseases in many Asian countries. Its analgesic effect has not been explored yet. This study aimed to test the analgesic potential of methanol extracts from Lonicera japonica (MELJ) in rat neuropathic mctel. Neuropathic pain was pacts ed by partial sciatic nerve injury. Two weeks after surgery, neuropathic rats received oral administration of MELJ at doses of either 0.0 g/kg, 0.2 g/kg or 0.4 g/kg. At dose of 0.0 g, rats were administered with saline only and used as conracl. The behavioral tests for f 0.0 g, raand ccld hs were adma were weformed up to 2 hours after treatment. The MELJ at the dose 0.4 g/kg dmg gfg, ntly alleviated f 0.0 g, rahyperalgesia, but not cold hyperalgesia. These results showed that the MELJ had, although transient, analgesic effect on mechanical hyperalgesia in the rat neuropathic model.
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KEYWORD
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Ionicera japonica, neuropathic pain, mechanical hyperalgesia
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